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Antioxidant enzyme-mimetics Superoxide dismutases (SODs), catalase (CAT), and glutathione peroxidases (GPxs) are the most important antioxidant enzymes playing key roles in redox homeostasis

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Journal of Cosmetic Dermatology, 22 (1), 262-266

This Polyol (Sorbitol) pathway is activated only if the concentration of glucose in cells is high because the enzyme Aldose reductase has a relatively low affinity for glucose (and conversely high Michaelis Menten constant K m )

C.CorteseI.BlakeA.OhayonJ.CherupJ.et al

Although RG7112 has better efficacy, the toxicities caused by RG7112 are varied and serious, which hinder its clinical use