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Preclinical and mechanistic studies were included selectively when they provided mechanistic insights (e.g., muscle metabolism, neural or hormonal pathways)

It is generally safe

Due to this loss of sensation, people with neuropathy may not realize they have injured their body part, which may lead to unexplained bruising. When blood glucose is elevated, it can interact with collagen, leading to skin changes in people with diabetes, says Neumiller

Those who follow a vegetarian or vegan diet may have trouble getting enough B12 from food alone

By blocking NNMT, it helps increase NAD+ levels, which in turn supports metabolic health and fat oxidation

Certain health conditions, physiological states, or expectations may increase risk or limit safety