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This section will systematically elaborate on two key processes underlying this proposed systemic inflammatory cascadenamely, the overflow of testicular inflammatory mediators into the circulation and the activation and migration of immune cellsand discuss their potential implications for distant organ function ( Figure 2 )
Elahi D, McAloon-Dyke M, Fukagawa NK, Sclater AL, Wong GA, Shannon RP, Minaker KL, Miles JM, Rubenstein AH, Vandepol CJ
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Records were excluded during screening if they were press releases, news reports, not relevant drug/indication/population, preclinical study, reviews, case reports, not a randomized trial, or not in humans
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