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In contrast, combining antioxidants with treatments that induce apoptosis through ROS-independent pathways may provide synergistic benefits and improve therapeutic outcomes

Slow escalation significantly reduces early gastrointestinal symptoms and increases the likelihood of sustained therapy

This is not a contradiction so much as a reflection of how complex the nervous system truly is

NH: Resources, Writing original draft

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Interestingly, they also report that in cell lines, stimulation rather than overexpression of IGF-1R is driving tamoxifen resistance to be abrogated by linsitinib