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What this data doesn't tell us: whether NNMT suppression sustained beyond 12 weeks alters NAD+ metabolism in ways that affect mitochondrial function, whether methylation pathway compensation occurs over longer timescales, or whether adipose tissue remodeling continues linearly or plateaus

It does not affect blood sugar levels

Product quality, delivery method, dosage, cycle length, and medical history all affect safety

The association is real and has been reproduced often enough that internists have written about it for years

Scientific Insights According to a study published in the Journal of Nutrition , individuals with higher B12 levels had a lower risk of obesity