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E., Monterrubio, E., Barquera, S

Most supervised programs use an active phase of 12 to 24 weeks followed by a lower-frequency maintenance phase rather than a hard stop

This endothelial protection aligns with the compounds nitric oxide pathway modulation and its ability to upregulate protective gene expression in vascular endothelial cells making it a potentially interesting subject for further cardiovascular research, particularly in the context of inflammation-driven vascular disease

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Most of what we know comes from preclinical and experimental research, rather than human trials