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New insights into the metabolic regulation of insulin action and insulin resistance: role of glucose and amino acids
GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) work by mimicking a natural hormone that regulates blood glucose and appetite
There are several possible advantages to their risky strategy
Retatrutide is an investigational triple-hormone receptor agonist developed by Eli Lilly that targets three receptors: GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon
The mechanistic case is coherent and supported by what we know about each modality separately
Management of Hyperglycemia in Type 2 Diabetes, 2018
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