In a randomized, double-blind, placebo-controlled crossover trial of 30 adults with obesity (Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity, Blundell and colleagues, Diabetes, Obesity and Metabolism , 2017), 12 weeks of once-weekly semaglutide titrated to 1.0 mg was associated with less hunger, fewer food cravings, better control of eating, and a lower preference for high-fat foods
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Some patients report mild nausea or fatigue at the beginning, but side effects are generally minimal
This article will focus on GLP-1 medications
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Additionally, semaglutide reduces appetite for food but does not reduce appetite for beverages, creating a disconnect where you may consume more alcohol than intended