Serious but rare class-relevant risks include pancreatitis, gallbladder disease, and a preclinical thyroid C-cell tumour signal
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Moreover, several large-scale clinical trials 6,7,8,9,10 such as LEADER, SUSTAIN-6, and REWIND have demonstrated that GLP-1RAs can reduce the incidence of MACEs in patients with T2D and established cardiovascular disease or high cardiovascular risk
Hyperammonemia is associated with various conditions including congenital lactic acidosis, dibasic amino acid transport defects, Reye syndrome, as well as drugs such as valproate, risperidone, or haloperidol