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Genetic variation in targets of antidiabetic drugs and Alzheimer disease risk

When amylin binds to these receptors, it triggers a cascade that makes you feel full sooner, slows the rate at which food leaves your stomach, and reduces the hedonic drive to eat, the pleasure-seeking component that makes high-calorie foods irresistible

Images were captured immediately before and 15 min after stimulation with 1 M GLP-1, for GLP-1R and GLP-1R/GIPR, or 1 M GIP, for GIPR and GIP/GLP-1R