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The before-February-2027 target gives a clear window

The 2025 Cochrane review discussed here evaluated the effectiveness and risks of GLP-1 agonists compared with placebo

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Wang ZJ, Han WN, Chai SF, Li Y, Fu CJ, Wang CF, Cai HY, Li XY, Wang X, Hlscher C, Wu MN (2024) Semaglutide promotes the transition of microglia from M1 to M2 type to reduce brain inflammation in APP/PS1/tau mice