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3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

The second is after a dose increase, when receptor stimulation intensifies

Increasing fiber intake, drinking plenty of water, and staying physically active are the first-line remedies

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DOI: 10.1177/0748233709348393 * These statements have not been evaluated by the Food and Drug Administration

The studys authors proposed that the cognitive effects of multivitamin/multimineral intervention may occur by activating vitamin and mineral receptors in the hippocampus, given its prominent role in recall memory