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This is especially true if overweight and obesity are excessively medicalized, leading to overutilization of expensive treatments, including current and emerging pharmacotherapies (168)
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Central Nervous System Drug Disposition: The Relationship between in Situ Brain Permeability and Brain Free Fraction
Alvarado AG, et al
Consider reducing to the previous tolerated dose for an additional 4 to 8 weeks before attempting re-escalation
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