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In a double blinded randomised study, daily injections of semaglutide (0.4 mg) in obese patients resulted in an average of 14% decrease in body weight, over placebo, after a year

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Furthermore, semaglutide treatment resulted in a significantly higher percentage of patients with NASH resolution than placebo in the phase II trial involving patients with NASH [80]

Genetic predisposition can modulate cellular sensitivity to apoptosis, and multiple regulatory factors are involved, including inflammatory mediators (IFN-, IL-2, IL-1), TSH, and anti-TPO antibodies

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