[22] [23] Versus DPP-4 inhibitors (such as sitagliptin), GLP-1 receptor agonists produce greater HbA1c reductions and weight loss, with some offering proven cardiovascular benefits
Activation of GLP-1R slows gastric emptying, enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon secretion, and produces a robust central satiety signal via vagal afferents and hypothalamic circuits
While PAP does lead to greater reductions in AHI and higher rates of complete treatment response when compared to MADs, patients are generally able to better tolerate MADs compared to PAP, with higher patient-reported compliance [36]
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Overweight, obesity, and blood pressure: the effects of modest weight reduction
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