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Compounds are not FDA-approved

Apparently the underlying thought is that it is necessary to keep the value between the (upper and lower) reference values

A short course of TB-500 does not produce the same remodeling outcome as a structured multi-phase protocol

Ng FM, et al

The typical regimen involves: Loading dose for patients without neurological involvement : Hydroxocobalamin 1mg intramuscularly three times weekly for two weeks [13] [10] Loading dose for patients with neurological involvement : Hydroxocobalamin 1mg on alternate days until no further improvement, then Maintenance therapy : 1mg every two to three months (or every two months if neurological involvement) Lifelong maintenance therapy is necessary for irreversible causes such as pernicious anaemia or following gastric surgery