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The relatively small final sample size may have reduced the statistical power, particularly regarding cardiac outcomes, while the six-month follow-up period may have been insufficient to detect long-term effects on cardiac remodeling

Deficiency causes megaloblastic anemia abnormally large, poorly functioning red blood cells which reduces the blood's oxygen-carrying capacity and contributes to fatigue, pallor, and shortness of breath

Stratifying by the presence or absence of endogenous C-peptide as a potential protective factor against DKA should also be investigated

they also accelerate the breakdown of existing collagen through the activation of enzymes called matrix metalloproteinases (MMPs)

Promotes metabolism