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A 2022 systematic review in Frontiers in Pharmacology identified 98 preclinical studies but zero controlled human pharmacokinetic trials [1]
Sci Rep 2015;5:9392
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Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible
Asparagine synthetase deficiency: new inborn errors of metabolism
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