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They require refrigeration and degrade over time

These processes include assisting in DNA synthesis and repair, supporting protein synthesis, and activating essential enzymes

J Alzheimers Dis 75:2228 Delalande O, Desvaux H, Godat E, Valleix A, Junot C, Labarre J, Boulard Y (2010) Cadmium-glutathione solution structures provide new insights into heavy metal detoxification

Utilisation en cas d'insuffisance rnale svre Chez les patients souffrant d'insuffisance rnale svre, les doses peuvent ventuellement tre augmentes (ou l'intervalle d'administration raccourci) car la rponse thrapeutique la vitamine B12 est parfois plus faible chez ces patients

10.1038/mi.2014.35 8 ChenJ.XuF.RuanX.SunJ.ZhangY.ZhangH.et al (2023a)