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Long-term safety and efficacy of glucagon-like peptide-1 receptor agonists in individuals with obesity and without type 2 diabetes: a global retrospective cohort study
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Physicians should observe for these adverse effects, notably in patients with comorbidities or polypharmacology
It is hypothesized that these differences might stem from IGF-1 LR3's diminished propensity to form complexes with IGFBPs, which might influence its bioavailability and interaction with target tissues in experimental models