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Materials and methods: A random sample of thirty-four participants with type 1 diabetes were consecutively included

Ferrous sulfate is cheap but notorious for causing constipation, nausea, and stomach upset

That is exactly what they are there for

PMID: 38272028 Int J Biol Macromol Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera

When gastric contents are retained longer, the prolonged distension of the stomach can create mechanical conditions that favor reflux, particularly when lying down or bending over