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Microbiome disruption GLP-1 medications like semaglutide slow digestion, which can alter the balance of bacteria in the gut
They also influence the circadian clock, the internal biological timer that determines when you feel awake and when you feel sleepy
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Drug interaction guide Originally published 25 Jan 2026 DownloadDownload Share Language Discussion Audio Version Add to preferred sources on Google Taking ibuprofen and diclofenac together significantly increases your risk of serious side effects, particularly stomach ulcers, internal bleeding, and kidney problems
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While the precise mechanism behind these headaches is not entirely clear, it is thought to be connected to the medications influence on blood vessels and neural pathways
