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N Engl J Med 392:21932202 Cao M, Luo X, Wu K, He X (2021) Targeting lysosomes in human disease: from basic research to clinical applications
When pain medications repeatedly failwhether through immune suppression, detox depletion, gut injury, hormonal disruption, or nervous system sensitizationit becomes clear that durable relief requires restoration of the biological systems responsible for healing , not further escalation of suppression
Int J Chron Obstruct
Research suggests this is linked to genetic variation in GLP-1 receptor expression
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