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Front Physiol [Internet]

Dendritic cells in the skin become activated by various triggers, including stress, infection, or injury

Melanin production is an ongoing biological process, and skin tone will gradually return towards baseline if treatment is discontinued and sun protection is neglected

extrapolating it into a claim of clean human endocrine selectivity is not supported

These signaling events are commonly assessed using enzyme activity assays, phosphorylation analysis, and gene expression profiling in laboratory systems