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Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis

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A unique side effect seen with Retatrutide 50mg but not with GLP-1 only medications is dysesthesia (a mild tingling or numbness sensation), which is believed to be related to glucagon receptor activation