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It functions by restoring key antioxidant enzymes and inhibiting proinflammatory cytokine production, mediated through the inhibition of MAPK and NF-B signaling pathways
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For example, a pooled analysis of two prospective cohort studies and six case-control studies found an inverse association between cruciferous vegetable consumption and risk of colorectal neoplasm in carriers of the GSTT1 null variant but not in individuals with the GSTM1 null variant or those with both the GSTT1 and GSTM1 null variants ( -/- ) (36)
Prior studies report that 15% or more of survivors experience a repeat overdose within a year, with the highest risk concentrated in the weeks immediately following the index event
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