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Neuropathy involves both microvascular nerve ischemia and direct Schwann cell/neuronal glucose toxicity
A 2019 review of studies was published in The Lancet
[3] GSTs are essential in this process because they catalyze the nucleophilic attack of glutathione on various electrophilic residues of xenobiotic substrates, thereby preventing their disruption of vital cellular proteins and nucleic acids
No blinding was performed
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