Funding This paper was supported by San Matteo Hospital Foundation, Internal Medicine research fundings, PRIN2017. Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
A practical trial design could use a mechanism-product matrix
miR-1246, released via exosomes from CRC cells, can reprogram tumor-associated macrophages (TAMs) toward a pro-tumor phenotype by altering their metabolic state, thereby supporting CRC growth and immune evasion [115]
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