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Enzymes are crucial to metabolism because they allow organisms to drive reactions that require energy and will not occur by themselves, by coupling them to spontaneous reactions that release energy
Nobiletin, a common natural flavonoid, has been found to activate mitophagy via AMPK and SIRT1 pathways, potentially alleviating D-galactose-induced mitochondrial damage in granulosa cells and delaying age-related apoptosis (Park et al., 2016
PMID 29733881
Int J Mol Sci 19 , (2018)
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