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all comparisons are cross-study AOD-9604 human safety data / Limited Phase IIb obesity trial (N=536) showed mild, transient adverse events MOTS-c human safety data / Confined to small pilot studies and case series

Tirzepatide's role in targeting adipose tissue macrophages to reduce obesity-related inflammation and improve insulin resistance

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PubMed Salles, N., Herrmann, F., Sakbani, K., Rapin, C

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Thus, the GLP-1 WT albiglutide-mimic has comparable FcRn binding characteristics as Tanzeum, while truncation of L585 from the C-terminal end of albumin decreases binding to the receptor