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Your genetic test results can guide whether a GIP-receptor agonist will suit you better than pure GLP-1 activation
These are usually less intense than the initial overlap period and resolve within days rather than weeks
Reframing this as successful adaptation rather than declining effectiveness helps maintain perspective
We also hypothesize that GLP-1 axons that are apposed to GLP-1R-negative SPNs may regulate these cells directly via synaptic glutamate release 58,59 , and indirectly by GLP-1 release that might modulate the activity of nearby GLP-1R + terminals on the surface of SPNs 60
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