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Genome-wide association analyses have detected critical polymorphisms in genes regulating hepatic lipid handling, including patatin-like phospholipase domain-containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), which promote intrahepatic triglyceride accumulation by impairing lipid remodeling or very-low-density lipoprotein (VLDL) secretion [16,17]

The next question, other than can this growth continue?, will be about real-world discontinuation rates and how growth in the high-dose category can continue there

Alz Res Therapy 17 , 269 (2025)

Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al

Wegovy (FlexTouch, injection) not reimbursed

Retatrutide, on the other hand, exhibits dose-dependent gastrointestinal effects that can be managed through gradual dose escalation