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Before using zonisamide, tell your health care provider about your medical history, especially if you have: kidney disease liver disease long-term diarrhea lung or breathing problems metabolic acidosis or diabetic ketoacidosis high ketone levels in your blood or urine you use insulin or other diabetes medications history of psychiatric disorders or suicidal thoughts Talk to your health care provider if you are planning to become pregnant or if pregnant or breastfeeding

The main symptoms are usually the appearance of fatigue and tiredness, loss of muscle mass and various gastrointestinal problems

While confounding variables complicate experiments, they also reflect the reality of human life

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But Sarah Hampl, MD, FAAP, a spokesperson for the AAP and a pediatrician who helped author the obesity guidance, rebutted those criticisms