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The initial dose is 3 mg by mouth once daily for 30 days
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Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles
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NICE Clinical Knowledge Summary (CKS) and NHS guidance emphasise the importance of addressing both reproductive and metabolic aspects of PCOS through lifestyle modification, pharmacological intervention when appropriate, and regular screening for associated comorbidities, including periodic HbA1c or glucose tolerance testing and lipid monitoring
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