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At the systemic level, GLP-1 RAs improve insulin sensitivity in peripheral tissues (muscle, adipose), reduce circulating free fatty acid flux to the liver, suppress hypothalamic appetite circuits to promote weight loss, and lower systemic pro-inflammatory cytokines (TNF-, IL-1, IL-6), thereby reducing the hepatic inflammatory milieu indirectly [7,26,30]
Use a fresh syringe for every injection
any abrasions were treated with 0.5% iodophor to prevent infection
Int J Mol Sci 2019;20:4092.ArticlePubMedPMC 27
W., Gravina, S
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