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Pinch the skin, insert the needle at a 45 to 90 degree angle (depending on body composition), inject slowly, hold for 5 to 10 seconds, withdraw

Jackson et al

PLoS Pathog 7 , e1002250 (2011)

Lack of Safety Data for Different Administration Routes FDA regulations require independent toxicological assessments for different administration routes, including topical, injectable, and oral administration

Treatment of B12 deficiency without neurological symptoms involves hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then every three months