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Individual animals with PPI-based evidence of NIT were subsequently treated with either NHPN-1010 or saline, wherein intervention was deliberately initiated four weeks (wks) after exposure

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(C) Relative mRNA expression of inflammatory genes in RAW264.7 macrophages exposed to metabolic stress (0.4 mM palmitate, 10 nM insulin, and 30 mM glucose) with or without Tir for 24 hours