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Stress reduction through gentle yoga practice, light exercise, meditation, and fasting from too much media can reduce emotional reactivity and settle the brain and gut.72-75 Stress and Cortisol: Addressing the Adrenal-Estrogen Connection Stress, coupled with cyclic hormonal changes, can spike cortisol levels, deplete progesterone, and interfere with detoxification and digestion.76 Some research has reported rapid declines in estrogen and progesterone levels during the late luteal phase create conditions that that contribute to premenstrual dysphoric disorder (PMDD), making coping with ordinary stresses feel even more challenging.77,78 Other clinical work shows that low estrogen and progesterone levels may also be tied to postpartum depression symptoms.78,79 But one thing that remains common is that out of balance cortisol release has negative consequences