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3 The role of S in PD Native S is a small monomeric presynaptic protein of 140 amino acids involved in vesicle trafficking, docking and fusion as well as neurotransmitter release and regulation, microtubule formation and axonal transport ( Although direct interconnections between the release of pro-inflammatory cytokines and S accumulation have yet to be established, altered pro-inflammatory cells in experimental PD models suggest that inflammation and S dysregulation are closely interconnected ( S has a high binding affinity for pre-synaptic vesicles and its accumulation in pre-synaptic terminals is a sign of synaptopathy

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The liver extracts and metabolizes glutathione efficiently, further reducing systemic bioavailability from the oral route

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