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Researchers also monitored hydration, digestive symptoms, and tolerance during ongoing dose escalation
Increased ATP7B expression facilitates copper export and reduces intracellular copper stress, thereby enabling CSCs to evade cuproptosis and acquire resistance
To advance the field, future research should prioritize refining therapeutic strategies, elucidating mechanisms, and developing personalized treatment approaches
Because coordinated cell migration is fundamental to how tissue reorganizes, TB-500 and Tb4 have been investigated in a broad set of preclinical models, including dermal repair, corneal models, and cardiac studies where actin dynamics and cell movement are central variables