Barry Conrad Well, you know, like 2026 could be the year of like giving it a good crack
We protected her cardiovascular system from years of additional damage
And then I said, okay, we definitely have to do this
Kwon DH, Cha HJ, Lee H, Hong SH, Park C, Park SH, Kim GY, Kim S, Kim HS, Hwang HJ, Choi YH
PMID: 40817224 Br J Pharmacol Microglial forkhead box O3a deficiency attenuates LPS-induced neuro-inflammation and depressive-like behaviour through regulating the expression of peroxisome proliferator-activated receptor-
Additionally, macrophages exhibit synergistic characteristics of dynamic phenotypic conversion and functional remodeling in response to DAMPs: during the acute injury phase, DAMPs (such as high-mobility group box protein B1 and adenosine triphosphate) activate the Toll-like receptor 4/P2X7 receptor pathway, which in turn activates the NF-B and NLRP3 inflammasome, driving macrophages toward M1 polarization and the secretion of pro-inflammatory factors such as interleukin-1(IL-1) and tumor necrosis factor- (TNF-), thereby establishing an efficient pathogen clearance mechanism (Gong et al., 2020) (86)
