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Think of it as a transport shuttle that carries long chain fatty acids across mitochondrial membranes so those fats can be burned through beta oxidation
All of these factors can contribute to poor production of glutathione (or of the enzymes that help glutathione to do its work), and many also deplete the GSH that the cells produce (by converting it into GSSG)
With biotin therapy (20 mg/day), her condition had improved quickly, although intermittent respiratory infections had led to metabolic acidosis and organic aciduria
Based on these findings a similar trial is warranted in CFS patients.
These results show that to reach a specific steady-state level of blood NAD + , different individuals required different dosages
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