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These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]

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The common thread is the quieting of something they call food noise, the ever-present hum of cravings, portion planning, emotional eating and food-based rituals

doi:10.1111/obr.13915 3

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The aim of this study was to audit the contemporary perspectives of PROM developers on the involvement of younger children in PROM development research