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Absorption issues: Some people, particularly those with gastrointestinal disorders or aging adults, may have trouble absorbing vitamin B12 through the digestive system

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60 In the canonical pathway, Wnt ligands bind Frizzled (FZD) receptors and LRP5/6 coreceptors, activating Dishevelled (DVL) and inhibiting the -catenin destruction complex (Axin/APC/GSK-3)