This usually resolves as the body adjusts
Amyotrophic Lateral Sclerosis (ALS) is a devastating multisystem neurodegenerative disease characterized by the degeneration of both upper (cortical) and lower (brainstem and spinal) motor neurons, leading to progressive voluntary muscle weakness and paralysis
So, for example, during expression and purification of a recombinant protein, it may have a disulfide bond form, which wouldnt normally form in the proteins natural context
620 Gene therapy Allotopic expression Mitochondrial proteins, encoded by nuclear genes, are synthesized in the cytoplasm before being imported into mitochondria
(Last Update: Jan 26, 2024) Han, T., Bai, J., Liu, W., & Hu, Y
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