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From a life-sciences and manufacturing vantage point, the question is not Melanotan 1 vs 2: which is safe? but Is any unregulated systemic tanning peptide justifiable when weighed against the reality of skin cancer and the uncertainties of underground peptide production? Melanotan I and II are clever pieces of peptide engineering that illustrate both the promise and peril of pharmacological tanning

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1,i , 2,i were assumed to be normally distributed, with a mean of 0 and variance of 1,i 2 , 2,i 2 , respectively

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The primers are listed in Supplementary Table 1

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