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In the SURPASS-1 trial, investigators reported an approximate 26% reduction in total fat mass compared with placebo

This approval was based on results from the Semaglutide Treatment Effect in People with Obesity program (STEP) clinical trials, which evaluated the safety and efficacy of semaglutide as an aid for losing weight in individuals without diabetes

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Some patients find that liquid protein sources (shakes, smoothies) are better tolerated than solid foods when nausea or early satiety is prominent

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