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Topiramate, known under the brand name Topamax, is an anti-seizure drug that was initially introduced as an epilepsy treatment in 1996
Aggregation of these disrupts normal cellular processes, such as protein degradation, resulting in cellular stress and, ultimately, cell death (Tsoi et al., 2023)
Protect at the Cellular Level Glutathione is often called the body's "master antioxidant." It's present in every cell and plays a central role in tissue repair, detoxification, protein synthesis, and immune function
Inhibition of HNF4 induces ferroptosis of EC We treated three types of EC with BI6015, a specific inhibitor of HNF4, and demonstrated that inhibition of HNF4 activity increased the sensitivity of EC to ferroptosis
Physiologically, it can bind to GLP-1 receptor on pancreatic beta cells through endocrine, activate adenylate cyclase, increase intracellular cAMP levels, promote glycolysis and ATP production, and enhance glucose-stimulated insulin secretion
Inositol Studies indicate it supports lipid metabolism and cell-membrane structure
