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Dietary factors play a significant role in symptom severity

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The activation of these events results in an increase in vasoconstriction and the promotion of thrombus formation, which can ultimately lead to the development of atherosclerosis (16)

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In these cases we recommend that an Eye Health care plan be put in place at the start of or soon after commencement of intensive glucose lowering treatment

Abbreviations BBB: Blood-brain barrier CGRP: Calcitonin gene-related peptide CM: Chronic migraine CNS: Central nervous system CSD: Cortical spreading depression DMEM: Dulbeccos modified Eagles medium FBS: Foetal bovine serum GLP-1R: Glucagon-like peptide-1 receptor IGF-1: Insulin-like growth factor-1 IS: Inflammatory soup LPS: Lipopolysaccharide NTG: Nitroglycerin PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PMSF: Phenylmethylsulfonyl fluoride RT: Room temperature TNC: Trigeminal nucleus caudalis References May A, Schulte LH (2016) Chronic migraine: risk factors, mechanisms and treatment