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Signaling pathways in immunosenescence Aberrant activation of various signaling pathways, including but not limited to the NF-B, mTOR, JAK-STAT, cGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes), AMPK (AMP-activated protein kinase), melatonin, and sirtuin pathways, plays a crucial role in regulating immune function during aging
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